miR-29b
نویسندگان
چکیده
منابع مشابه
miR-29b
Multiple myeloma (MM) is a heterogeneous disease originating from the transformation of a post-germinal center B cell. MM pathogenesis is a multistep process with chro-mosomal changes, genetic and epigenetic events occurring at different stages during the course of the disease. 1 MicroRNAs (miRNAs) are well known to be transcriptional repressors, possessing tumor suppressor (Ts) or oncogenic fu...
متن کاملExpression of miR-29b in Malignant Tumors
MicroRNAs (miRNAs) are a class of single-stranded small molecule RNA with about 22 nucleotides in length (Bartel, 2009). These short RNA molecules are able to bind to specifics sites typically present in the three prime untranslated region (3’-UTR) of their target genes and mediate either mRNA decay with perfect base pairing or translational blockade with imperfect base pairing (Pillai et al., ...
متن کاملExpression Analysis of Cellular Mir-29a and mir-29b in HIV Positive Patients
Abstract Background and Objective: Various cellular factors affect the process of HIV activity. One of these cellular factors are structures known as microRN that are expected to be involved in controlling HIV replication and infectivity. The expression of one or a set of them may represent the patient's clinical conditions. In this study, ...
متن کاملmiR-29b, miR-205 and miR-221 Enhance Chemosensitivity to Gemcitabine in HuH28 Human Cholangiocarcinoma Cells
BACKGROUND AND AIMS Cholangiocarcinoma (CCA) is highly resistant to chemotherapy, including gemcitabine (Gem) treatment. MicroRNAs (miRNAs) are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play important roles in the chemosensitivity of tumors. Here, we examined the relationship between miRNA expression and the sensitivity of CCA cells to Gem. ME...
متن کاملMicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism significantly contributes to cancer onset and progression. Here, we report that miR-29b negatively regulates AKT2/AKT3 expression, causing HK2/PKM2 downregulation and leading to a decreased Warburg effect and slowed ovarian cancer progression. Compared to normal ovaries, ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.26975